Detalles de la búsqueda
1.
Small-molecule inhibitors of human mitochondrial DNA transcription.
Nature;
588(7839): 712-716, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33328633
2.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Nature;
507(7493): 508-12, 2014 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24553136
3.
A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.
Antimicrob Agents Chemother;
59(4): 2062-71, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25624324
4.
Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species.
Cell Physiol Biochem;
36(6): 2237-49, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26279429
5.
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland.
Eur J Med Chem;
265: 116053, 2024 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38141285
6.
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.
Nat Metab;
2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38689023
7.
Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form.
J Med Chem;
66(10): 6959-6980, 2023 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37191268
8.
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation.
Eur J Med Chem;
255: 115344, 2023 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37141705
9.
Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety.
Mol Metab;
75: 101775, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37451343
10.
Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis.
Biomed Pharmacother;
168: 115698, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37865992
11.
Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt.
J Med Chem;
64(13): 9238-9258, 2021 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34008974
12.
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
J Med Chem;
63(20): 11725-11755, 2020 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32931277
13.
Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain.
Eur J Pharmacol;
845: 48-55, 2019 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30582910
14.
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.
Cancer Res;
79(9): 2367-2378, 2019 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30858154
15.
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Chem Sci;
10(46): 10789-10801, 2019 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31857889
16.
In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.
Drug Metab Dispos;
36(5): 894-903, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18268076
17.
Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia.
Oncotarget;
9(41): 26353-26369, 2018 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-29899864
18.
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
Oncotarget;
9(51): 29634-29643, 2018 Jul 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30038709
19.
Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection.
Cell Host Microbe;
23(5): 661-671.e8, 2018 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29706504
20.
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
J Med Chem;
60(13): 5290-5305, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28613871